Obsah:
- 12 použití a výhod klinčekového oleja
- 1. Môže zmierniť bolesť zubov
- 2. Môže pomôcť pri liečbe kožných chorôb a akné
- 3. Môže mať analgetické vlastnosti
- 4. Môže pomôcť tráveniu
- 5. Môže posilniť imunitný systém
- 6. Môže mať antimikrobiálne vlastnosti
- 7. Môže pôsobiť ako repelent proti hmyzu
- 8. Môže znížiť bolesť žalúdka
- 9. Môže zvýšiť kardiovaskulárne zdravie
- 10. Môže podporovať rast vlasov
- 11. May Have Anticancer Properties
- 12. May Act As An Aphrodisiac
- Other Uses of Clove Oil
- How To Use Clove Oil To Treat A Toothache?
- How To Use Clove Oil?
- Spray
- To make a clove spray:
- Diffuser
- Topically
- Massage oils
- Creams, scrubs, or lotions
- How Do You Use Clove Oil For Hair Growth?
- Are There Any Side Effects Of Using Clove Oil?
- Hepatotoxicity
- May Cause Skin irritation
- May Cause Allergies
- Drug Interactions
- What To Look For When Buying Clove Oil
- Look for a purity statement on the label
- Don’t go by the marketing hype
- Make sure the clove oil is in a dark glass bottle
- If you can, smell it before buying it
- Conclusion
- Expert’s Answers For Readers’ Questions
- 61 sources
Z klinčekového stromu sa extrahuje klinčekový olej. Je to para destilovaná z klinčekových púčikov, ktoré majú ostrý štipľavý zápach. Je pôvodom z juhovýchodnej Ázie a po celé storočia sa používa na liečbu bolesti spojenej s problémami so zubami.
O klinčekovom oleji sa hovorí, že má antioxidačné, antimikrobiálne, protiplesňové, protizápalové a anestetické vlastnosti (1, 2). Môže tiež pomôcť pri liečbe kožných ochorení, pomôcť tráveniu a posilniť imunitný systém. Tento článok pojednáva o možných zdravotných výhodách, použití a vedľajších účinkoch klinčekového oleja. Čítajte ďalej a dozviete sa viac.
12 použití a výhod klinčekového oleja
1. Môže zmierniť bolesť zubov
Klinčekový éterický olej môže pomôcť zabrániť dutinám a zmierniť bolesť ústnej dutiny. Tradične sa používa na zmiernenie bolesti zubov. Používa sa tiež na urgentné prípady zubov, ako sú zápaly úst alebo hrdla. Uvádza sa tiež, že klinčekový olej sa používa pri príprave určitých zubných pást a ústnych vôd (3). Eugenol, aromatická olejovitá kvapalina extrahovaná z klinčekového oleja, sa používa ako sedatívum pri zubných zákrokoch (4). Klinček má tiež vlastnosti proti plaku. Môže inhibovať množenie orálnych baktérií, ktoré môžu spôsobiť zubný povlak (5).
Zistilo sa tiež, že klinčekový éterický olej vykazuje antikarogénnu a cytotoxickú aktivitu proti veľkému počtu orálnych patogénov (6). Eugenol a eugenylacetát sú dve aktívne zložky v klinčekovom éterickom oleji, ktoré pomáhajú predchádzať odvápňovaniu alebo erózii zubov (7). Klinčekový olej je najúčinnejší proti mikroorganizmom, ktoré spôsobujú zubný kaz (8).
2. Môže pomôcť pri liečbe kožných chorôb a akné
Klinčekový olej údajne pôsobí proti Propionibacterium acnes, baktériám, ktoré spôsobujú akné (9). Na dosiahnutie ďalších záverov je však potrebných viac štúdií v tejto oblasti.
Štúdia vykonaná na Dermatologickom oddelení v Káhire v Egypte zistila, že klinčekový olej bol účinný pri topickej liečbe chronického svrbenia (10).
Ďalšia štúdia, ktorú uskutočnila univerzitná nemocnica v Mansoura v Egypte, zistila, že lokálna aplikácia krému z klinčekového oleja môže pomôcť pri liečbe chronických análnych trhlín (11).
3. Môže mať analgetické vlastnosti
Zistilo sa, že klinčeková olejová masáž účinne znižovala bolesti chrbta u postnatálnych matiek (12). Hovorí sa, že klinčekový olej má analgetické vlastnosti, ktoré znižujú bolesť zubov a bolesti kĺbov aktiváciou vápnikových a chloridových kanálov v lymfatických uzlinách (13). Eugenol v klinčeku bol tiež študovaný kvôli jeho analgetickým účinkom (14). Klinčekový olej môže tiež zmierniť bolesť u myší (15).
Ďalšia štúdia uskutočnená na Kuvajtskej univerzite zistila, že klinčekový gél môže mať potenciál nahradiť benzokaín ako topické anestetikum (16).
4. Môže pomôcť tráveniu
Klinčekový olej môže pomôcť zmierniť nevoľnosť, zvracanie a kinetózu vďaka svojim anti-dráždivým a upokojujúcim vlastnostiam (17). Eugenol v klinčekovom éterickom oleji má schopnosť stimulovať syntézu hlienu, dôležitého gastroprotektívneho faktora (18). Na pochopenie jeho použitia pri liečbe žalúdočných vredov je však potrebný ďalší výskum.
5. Môže posilniť imunitný systém
Eugenol v klinčekoch chráni bunkové membrány pred poškodením voľnými radikálmi a oxidačným stresom (19). V jednej štúdii na zvieratách mohol olej pôsobiť aj ochranne pred oxidačným stresom vyvolaným žiarením (20). Klinčekový olej má údajne protizápalové účinky. Štúdia preukázala, že klinčekový olej má od dávky závislý protizápalový účinok na potkany Wistar (21). Zistilo sa tiež, že olej mal antinociceptívne a antipyretické účinky na myši (22).
6. Môže mať antimikrobiálne vlastnosti
Klinčekový éterický olej je silným zdrojom antimikrobiálnych látok, ktoré pôsobia najmä proti bakteriálnym patogénom (23). Olej môže byť účinný pri zastavení rastu niekoľkých druhov baktérií a tiež pôsobiť proti patogénom dýchacích ciest (24). Zistilo sa tiež, že klinčekový olej účinkuje proti klinickým kmeňom Escherichia coil , špecifickej baktérii, ktorá je vysoko rezistentná na niekoľko antibiotík (25). Štúdia, ktorú vykonala sekcia mikrobiológie a technológií pre morské plody v Španielsku, zistila, že klinčekový éterický olej účinne ničí biofilmy Staphylococcus aureus (26) .
Okrem toho, klinčekový olej účinkuje proti Candida albicans, ktorá spôsobuje afty, ústnu dutinu a pošvové kvasinkové infekcie. Eugenol v klinčekovom oleji by mohol mať antikandicídny účinok (27). Štúdia, ktorú uskutočnila Toyama Medical and Pharmaceutical University, zistila, že kombinácia acykloviru Štúdia uskutočnená Toyama Medical and Pharmaceutical University zistila, že kombinácia acykloviru (antivírusový liek) a klinčeka na myšiach môže liečiť vírusovú infekciu herpes simplex (28)). Zmes éterických olejov s klinčekovým olejom by mohla chrípkový vírus výrazne oslabiť. Vírusy ošetrené olejovou zmesou mali minimálnu expresiu vírusových proteínov. To znamená, že klinčekový olej by mohol mať schopnosť bojovať proti určitým vírusom, ktoré spôsobujú infekcie (29).
7. Môže pôsobiť ako repelent proti hmyzu
Klinčekový olej môže pôsobiť ako repelent proti hmyzu a zabrániť chorobám prenášaným vektormi (spôsobených u ľudí parazitom) (30). Štúdia zistila, že zložky klinčekového éterického oleja môžu byť potenciálne užitočné pri výrobe repelentov proti všiam (31). Klinčekový olej môže tiež vykazovať repelentnú aktivitu proti japonským termitom (32).
Štúdia uskutočnená na Mahidolskej univerzite v Thajsku zistila, že klinček essentialoil môže odpudzovať chrobáky Leptotrombidium , ktoré sú druhom lariev. Olej môže byť tiež bezpečnejšou a lacnejšou alternatívou k syntetickým repelentom, ktoré môžu spôsobovať vedľajšie účinky (33). Klinčekový éterický olej tiež vykazoval odpudivosť proti Leptotrombidium deliense , ďalšiemu druhu lariev (34). Zistilo sa tiež, že formulácia obsahujúca klinčekový éterický olej je účinná proti komárom Aedes aegypti (35).
Eugenol v klinčekovom oleji by mohol tiež slúžiť ako sľubná alternatíva k bežným insekticídom (36). Zistilo sa, že Eugenol, eugenol-acetát a beta-karyofylén, bioaktívne chemikálie v klinčekoch, majú schopnosť odpudzovať červené mravce (37).
8. Môže znížiť bolesť žalúdka
Bolo navrhnuté, že eugenol v klinčekovom oleji je prospešný pre gastrointestinálne ťažkosti, ako sú bolesti brucha. Používa sa tiež na liečbu kašľa, hlienov a preťaženia hrudníka (38). Na zníženie bolesti žalúdka sa môže použiť klinček. Na podporu tohto tvrdenia sú však k dispozícii obmedzené údaje.
9. Môže zvýšiť kardiovaskulárne zdravie
Klinčekový olej môže pomôcť zlepšiť kardiovaskulárne zdravie. Tradične je známe, že zlepšuje krvný obeh. Štúdia na potkanoch ukázala, že eugenol v oleji rozšíril mozgové tepny. To u ľudí môže znamenať znížené riziko mozgovej príhody (39). U potkanov mohla liečba eugenolom znížiť hladinu krvného tlaku a dokonca spomaliť srdcovú frekvenciu (40). V inej štúdii potkany kŕmené vysokým obsahom fruktózy, keď dostali klinčekový éterický olej, preukázali zlepšenie tukovej pečene. Olej mohol tiež regulovať hladinu cholesterolu u potkanov. Štúdia naznačuje možné kardioprotektívne vlastnosti klinčekového oleja (41).
U diabetických potkanov môže klinický olej vykazovať aj kardioprotektívne účinky. Môže to byť spôsobené antioxidačnými vlastnosťami oleja (42). Ďalšia štúdia dospela k záveru, že eugenol môže byť terapeuticky užitočný ako antihypertenzívum (43).
10. Môže podporovať rast vlasov
Eugenol is known to stimulate the hair roots. A formulation containing clove oil was found to condition hair and enhance its growth. It could repair the hair shaft (44). However, more studies in this line are needed to reach further conclusions.
11. May Have Anticancer Properties
Eugenol was identified as one of the agents that could have anticancer properties. It may also prevent the proliferation of cancer cells and can help with cancer cell death (apoptosis) (45).
In another study, eugenol could suppress the growth of melanoma or skin cancer. Eugenol treatment could reduce tumor size by 40% and also delayed the growth of tumors (46). The National Toxicology Program based on several long term carcinogenicity studies concluded that eugenol was not carcinogenic to rats (47). Similar observations could be expected in humans as well.
In another study, clove extract was found to inhibit tumor growth. It could be a novel treatment for colorectal cancer (48).
However, it is important to practice caution, as eugenol may also have certain prooxidant properties. The compound may cause allergies and other inflammatory reactions (49).
12. May Act As An Aphrodisiac
In studies on male mice, extracts of clove (along with nutmeg) could enhance sexual behavior (50). In another study, 50% ethanolic extract of clove produced a significant and sustained increase in the sexual activity of normal male rats. The extract also caused no adverse effects (51). However, more studies are warranted in this regard.
These are the major benefits of clove oil. The oil also has other important uses, which we will explore in the following section.
Other Uses of Clove Oil
- Clove oil blended with cinnamon, orange, nutmeg, or vanilla oils can lift one’s spirits. Using this warming blend in a diffuser will soon fill the room and may also relieve stress.
- Anecdotal evidence suggests that sniffing the spicy aroma of cloves reduces drowsiness and fatigue, irritability, and headaches. It may stimulate the mind and also increase memory recall.
- Cloves encourage the loosening of phlegm from the respiratory system. They also promote sweating during fevers, colds, and flu, which can be very healing. Clove oil is often used in remedies for coughs.
- Like many culinary spices, clove may help relax the smooth muscle lining of the digestive tract. A few drops of the oil in water can relieve nausea. Clove tea may help treat diarrhea, gas, bloating, and intestinal spasms.
- Clove oil stimulates circulation and blood flow to the skin. This may help those with cold extremities.
- Clove oil is as effective as oil of oregano in treating athlete’s foot, nail fungus, and other skin problems. It can be applied directly to the skin or nails (unless the skin is sensitive or broken, wherein it must be diluted with extra virgin olive oil or unrefined coconut oil).
- One drop of clove oil applied to the roof of the mouth may relieve headaches. However, more research is warranted in this regard.
- Clove oil is long used in aromatherapy to relieve pain. For general pain relief, add 3 drops of clove oil to 1 teaspoon of coconut oil or extra virgin olive oil. Apply it to the pain areas.
- A band-aid soaked in a few drops of clove oil can help treat warts. Applying the band-aid to warts may help dissolve them if done regularly for a few weeks.
Clove oil is popularly known as a remedy for toothache. Using oil to relieve tooth pain is simple. Check the following section
How To Use Clove Oil To Treat A Toothache?
Dentists use clove oil as an oral anesthetic and also to disinfect root canals. The oil stops the toothache when dropped into the oral cavity. For temporary relief, dip a cotton swab in clove oil and apply it to the affected tooth. Adding a clove or two to a cup of tea can work miracles on a toothache.
Here is how you can use clove oil to relieve your toothache:
- Dilute a few drops of clove oil in an edible carrier oil, such as olive or coconut oils.
- Dab a clean cotton ball into the solution, and allow it to soak in it.
- Avoiding contact with your gums, apply the cotton ball to the sore tooth. It may take a few minutes of application for you to feel the relief.
- Apply every 2 hours or as necessary.
You can use clove oil in various other ways to achieve its benefits. In the following section we have discussed its most popular uses.
How To Use Clove Oil?
Spray
Using the clove oil as a spray is an easy way to add the clove scent to your room. Clove oil possesses antimicrobial properties, and you can also use it as a mild disinfectant.
To make a clove spray:
- Add several drops of clove oil to water. You would need 10 to 15 drops of clove oil per ounce of water to prepare the spray.
- Add it to a spray bottle. Be sure to shake the bottle well before spraying.
Diffuser
You can also use the oil in a diffuser. While diffusing clove oil, carefully follow the instructions that come with the diffuser. Make sure the room is well-ventilated when you diffuse the clove oil.
Topically
You can apply clove oil to your skin to achieve different benefits.
Massage oils
Use 15 drops of clove oil per ounce of carrier oil to create a 2.5 percent solution of massage oil. This solution can be used as a massage oil for pain relief.
Creams, scrubs, or lotions
For use on normal skin, you need 1 to 2.5 percent dilution of clove oil. For sensitive skin, you need 0.5 to 1 percent dilution of the oil. This diluted solution has no aroma and can be used in the preparation of several scrubs, lotions, or creams.
How Do You Use Clove Oil For Hair Growth?
There is not enough information in this regard. But anecdotal evidence suggests that clove oil acts as a natural remedy to promote hair growth as it contains a number of vital vitamins and minerals. Massaging diluted clove oil into your scalp may boost blood circulation. This could ensure more nutrients and oxygen are supplied to your scalp and hair follicles. To experience the benefits of clove essential oil for hair growth, you can indulge in a hot oil treatment or apply a DIY hair mask prepared with clove oil.
Though clove oil is well studied for its benefits, it may not be suitable for all. The oil may cause side effects in some.
Are There Any Side Effects Of Using Clove Oil?
Clove oil may cause local irritation, rare allergic reactions, and contact dermatitis in some individuals. More severe effects include tissue injury and acute onset of seizures, coma, and damage to the liver and kidneys (52). Clove essential oil is generally recognized as a safe substance when consumed in concentrations lower than 1500 mg/kg. The World Health Organization (WHO) established that the daily quantity acceptable of clove per day is 2.5 mg for every kg of body weight in humans (53).
Hepatotoxicity
High doses of eugenol may harm the liver and kidneys, as per some rat studies. Several instances of severe acute liver and kidney injury have been reported after an accidental overdose of eugenol containing herbal products, largely in infants (54), (55).
May Cause Skin irritation
Excess usage of clove oil can cause skin irritation in some people. Eugenol is an effective substance that is incorporated into many dental products. Contact dermatitis due to this chemical is not unusual. However, true serious allergic reactions are extremely rare (56).
As a primary irritant and sensitizer, eugenol is known to cause contact urticaria as well as chronic urticaria (rashes with dangerous swelling) (57). If you are concerned about your sensitivity to this essential oil, do a patch test before using it. Apply a small amount of diluted clove oil to the inside of your elbow. If you notice signs of skin irritation, like redness, itching, or swelling, don’t use clove oil topically.
May Cause Allergies
It is very rare to have an allergic reaction due to clove oil. The eugenol in the oil may cause oral irritation and heat sensation on the tongue (58).
Drug Interactions
Medications that slow blood clotting (anticoagulant/antiplatelet drugs) interact with clove. Hence, avoid using clove oil if you are taking any anticoagulants. Acetyl eugenol, a component of clove oil (Syzygium aromaticum L.), inhibits platelet aggregation in humans. This could lead to bleeding (59), (60).
Avoid using clove oil if you have had a recent major surgery, peptic ulcers, or bleeding disorders, such as hemophilia.
You can buy clove oil from your nearest health store. But before you make a purchase, you need to keep a few things in mind.
What To Look For When Buying Clove Oil
Look for a purity statement on the label
Try to buy 100 percent clove essential oil and look for other ingredients listed (if any).
Don’t go by the marketing hype
Generally, essential oils are not regulated by the Food and Drug Administration (FDA) in the same way as drugs. Hence, you should be more cautious of any oil that claims to cure a specific condition.
Make sure the clove oil is in a dark glass bottle
Light has the potential to damage essential oils. Dark glass helps keep the light out. Always ensure your product comes packaged in a dark glass bottle.
If you can, smell it before buying it
Clove essential oil has a unique fragrance. Smell it before buying. If it does not smell natural, avoid purchasing it.
Conclusion
Clove oil possesses many therapeutic properties and has several health benefits. From dealing with dental problems to treating cardiovascular issues, this essential oil can improve human health in various ways. However, excess usage may cause several side effects. Hence, limit its use and consult your doctor if you experience any adverse effects.
Expert’s Answers For Readers’ Questions
Can you drink clove oil?
Ingestion of clove oil can be dangerous. Clove oil ingestion may result in coma, fits, and acute liver damage (61).
Can clove oil damage teeth?
Clove oil is generally considered safe for teeth.
How often can I use clove oil on my tooth?
If you are suffering from toothache, you can use it every 3-5 hours for relief. If you have multiple pain points in your mouth after a dental procedure, you can add a few drops of clove oil to coconut oil and swirl it in your mouth.
Does clove oil help you sleep?
The oil contains eugenol that is a mild anesthetic. It may aid in sleeping. Apply a few drops of warm clove oil with some carrier oil on your forehead for better sleep.
Can you apply clove oil directly to the skin?
First, do a patch test after diluting the oil with a carrier oil. If there is no reaction, you can apply clove oil to your skin.
How long does clove oil take to work?
Clove oil may soothe a toothache and relieve pain within minutes. It generally takes 5-10 minutes to work.
61 sources
Stylecraze má prísne pokyny pre získavanie zdrojov a spolieha sa na odborné štúdie, akademické výskumné inštitúcie a lekárske asociácie. Vyhýbame sa použitiu terciárnych odkazov. Ďalšie informácie o tom, ako zabezpečujeme presnosť a aktuálnosť nášho obsahu, sa dozviete v našich redakčných pravidlách.- Milind, Parle a Khanna Deepa. "Klinček: šampiónske korenie." Int J Res Ayurveda Pharm 2.1 (2011): 47-54.
www.researchgate.net/publication/267402397_Clove_A_champion_spice
- Cortés-Rojas, Diego Francisco a kol. „Klinček (Syzygium aromaticum): vzácne korenie.“ Ázijský tichomorský časopis tropickej biomedicíny zv. 4,2 (2014): 90-6.
www.ncbi.nlm.nih.gov/pmc/articles/PMC3819475/
- Kumarswamy, A. “Multimodal management of dental pain with focus on alternative medicine: A novel herbal dental gel.” Contemporary clinical dentistry vol. 7,2 (2016): 131-9.
www.ncbi.nlm.nih.gov/pmc/articles/PMC4906852/
- Kozam, George. “The effect of eugenol on nerve transmission.” Oral Surgery, Oral Medicine, Oral Pathology 44.5 (1977): 799-805.
www.sciencedirect.com/science/article/abs/pii/0030422077903905
- Kothiwale, Shaila V., et al. “A comparative study of antiplaque and antigingivitis effects of herbal mouthrinse containing tea tree oil, clove, and basil with commercially available essential oil mouthrinse.” Journal of Indian Society of Periodontology 18.3 (2014): 316.
www.ncbi.nlm.nih.gov/pmc/articles/PMC4095623/
- Kouidhi, Bochra, Tarek Zmantar, and Amina Bakhrouf. “Anticariogenic and cytotoxic activity of clove essential oil (Eugenia caryophyllata) against a large number of oral pathogens.” Annals of microbiology 60.4 (2010): 599-604.
link.springer.com/article/10.1007/s13213-010-0092-6
- Marya, Charu M et al. “In vitro inhibitory effect of clove essential oil and its two active principles on tooth decalcification by apple juice.” International journal of dentistry vol. 2012 (2012): 759618.
www.ncbi.nlm.nih.gov/pmc/articles/PMC3432374/
- Kanth, M Rajini et al. “Efficacy of Specific Plant Products on Microorganisms Causing Dental Caries.” Journal of clinical and diagnostic research: JCDR vol. 10,12 (2016): ZM01-ZM03. doi:10.7860/JCDR/2016/19772.9025
www.ncbi.nlm.nih.gov/pmc/articles/PMC5296592/
- Fu, YuJie, et al. “The antibacterial activity of clove essential oil against Propionibacterium acnes and its mechanism of action.” Archives of dermatology 145.1 (2009): 86-88.
jamanetwork.com/journals/jamadermatology/article-abstract/711838
- Ibrahim IM, Elsaie ML, Almohsen AM, Mohey-Eddin MH. Effectiveness of topical clove oil on symptomatic treatment of chronic pruritus. J Cosmet Dermatol . 2017;16(4):508‐511.
pubmed.ncbi.nlm.nih.gov/28382655/
- Elwakeel HA, Moneim HA, Farid M, Gohar AA. Clove oil cream: a new effective treatment for chronic anal fissure. Colorectal Dis . 2007;9(6):549‐552.
pubmed.ncbi.nlm.nih.gov/17573751/
- Nethravathi, V., and V. Vijaitha. “Effectiveness of Clove oil massage on Lower Back Pain among Post Natal Mothers at Selected Hospitals, Bangalore.” Asian Journal of Nursing education and research 5.4 (2015): 467-470.
www.researchgate.net/publication/286523804_Effectiveness_of_Clove_oil_massage_on_Lower_Back_Pain_among_Post_Natal_Mothers_at_Selected_Hospitals_Bangalore
- Cortés-Rojas, Diego Francisco et al. “Clove (Syzygium aromaticum): a precious spice.” Asian Pacific journal of tropical biomedicine vol. 4,2 (2014): 90-6. doi:10.1016/S2221-1691(14)60215-X
www.ncbi.nlm.nih.gov/pmc/articles/PMC3819475/#b30
- Li, Hai Ying et al. “Eugenol Inhibits ATP-induced P2X Currents in Trigeminal Ganglion Neurons.” The Korean journal of physiology & pharmacology: official journal of the Korean Physiological Society and the Korean Society of Pharmacology vol. 12,6 (2008): 315-21. doi:10.4196/kjpp.2008.12.6.315
www.ncbi.nlm.nih.gov/pmc/articles/PMC2788653/
- Halder, Sumita, et al. “Acute effect of essential oil of Eugenia caryophyllata on cognition and pain in mice.” Naunyn-Schmiedeberg’s archives of pharmacology 385.6 (2012): 587-593.
link.springer.com/article/10.1007%2Fs00210-012-0742-2
- Alqareer A, Alyahya A, Andersson L. The effect of clove and benzocaine versus placebo as topical anesthetics. J Dent . 2006;34(10):747‐750.
pubmed.ncbi.nlm.nih.gov/16530911/
- Duarte, R. C., et al. “Irradiation effect on antifungal potential of clove essential oil.” Science And Technology Against Microbial Pathogens: Research, Development and Evaluation . 2011. 236-240.
www.worldscientific.com/doi/abs/10.1142/9789814354868_0046
- Santin JR, Lemos M, Klein-Júnior LC, et al. Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models. Naunyn Schmiedebergs Arch Pharmacol . 2011;383(2):149‐158.
pubmed.ncbi.nlm.nih.gov/21140134/
- Kumaravelu, Parasakthy, et al. “The antioxidant effect of eugenol on CCl4-induced erythrocyte damage in rats.” The Journal of Nutritional Biochemistry 7.1 (1996): 23-28.
www.sciencedirect.com/science/article/abs/pii/095528639500162X
- Abdel-Magied, N., and A. G. Ahmed. “Efficacy of clove oil as an antioxidant against radiation risk in male rats.” Journal of Radiation Research and Applied Sciences 4.3 (2011): 939-955.
inis.iaea.org/search/search.aspx?orig_q=RN:44083430
- Humbal, Brijesh R., et al. “Evaluation of in-vivo anti-inflammatory activity of Syzygium aromaticum oil in male wistar rats.” (2019).
www.researchgate.net/publication/334735954_Evaluation_of_in-vivo_anti-inflammatory_activity_of_Syzygium_aromaticum_oil_in_male_wistar_rats
- Taher, Yousef A., et al. “Experimental evaluation of anti-inflammatory, antinociceptive and antipyretic activities of clove oil in mice.” Libyan Journal of Medicine 10.1 (2015): 28685.
www.tandfonline.com/doi/full/10.3402/ljm.v10.28685
- Nuñez, L, and M D’ Aquino. “Microbicide activity of clove essential oil (Eugenia caryophyllata).” Brazilian journal of microbiology: vol. 43,4 (2012): 1255-60.
www.ncbi.nlm.nih.gov/pmc/articles/PMC3769004/
- Ács, Kamilla et al. “Antibacterial activity evaluation of selected essential oils in liquid and vapor phase on respiratory tract pathogens.” BMC complementary and alternative medicine vol. 18,1 227. 27 Jul. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6064118/
- Santa Packyanathan, Jerusha, and Gopinath Prakasam. “Antibacterial Effect of Clove Oil against Clinical Strains of Escherichia coli.” Journal of Pharmaceutical Sciences and Research 9.7 (2017): 1203.
search.proquest.com/openview/8bf3b96982be7f97c4f86c4dd8ae3dd9/1?pq-origsite=gscholar&cbl=54977
- Vázquez-Sánchez D, Cabo ML, Rodríguez-Herrera JJ. Antimicrobial activity of essential oils against Staphylococcus aureus biofilms. Food Sci Technol Int . 2015;21(8):559‐570.
pubmed.ncbi.nlm.nih.gov/25280938/
- Chami N, Bennis S, Chami F, Aboussekhra A, Remmal A. Study of anticandidal activity of carvacrol and eugenol in vitro and in vivo. Oral Microbiol Immunol . 2005;20(2):106‐111.
pubmed.ncbi.nlm.nih.gov/15720571/
- Kurokawa M, Nagasaka K, Hirabayashi T, et al. Efficacy of traditional herbal medicines in combination with acyclovir against herpes simplex virus type 1 infection in vitro and in vivo. Antiviral Res . 1995;27(1-2):19‐37.
pubmed.ncbi.nlm.nih.gov/7486956/
- Wu, Shuhua et al. “Protective essential oil attenuates influenza virus infection: an in vitro study in MDCK cells.” BMC complementary and alternative medicine vol. 10 69. 15 Nov. 2010.
www.ncbi.nlm.nih.gov/pmc/articles/PMC2994788/
- Shapiro, Rochel. “Prevention of vector transmitted diseases with clove oil insect repellent.” Journal of pediatric nursing 27.4 (2012): 346-349.
www.sciencedirect.com/science/article/abs/pii/S0882596311001898
- Iwamatsu, Takuma, et al. “Identification of repellent odorants to the body louse, Pediculus humanus corporis, in clove essential oil.” Parasitology research 115.4 (2016): 1659-1666.
link.springer.com/article/10.1007/s00436-016-4905-9
- Park, Il-Kwon, and Sang-Chul Shin. “Fumigant activity of plant essential oils and components from garlic (Allium sativum) and clove bud (Eugenia caryophyllata) oils against the Japanese termite (Reticulitermes speratus Kolbe).” Journal of Agricultural and Food Chemistry 53.11 (2005): 4388-4392.
pubs.acs.org/doi/abs/10.1021/jf050393r
- Eamsobhana P, Yoolek A, Kongkaew W, et al. Laboratory evaluation of aromatic essential oils from thirteen plant species as candidate repellents against Leptotrombidium chiggers (Acari: Trombiculidae), the vector of scrub typhus. Exp Appl Acarol . 2009;47(3):257‐262.
pubmed.ncbi.nlm.nih.gov/19009361/
- Hanifah, Azima Laili, et al. “Laboratory evaluation of six crude plant extracts as repellents against larval Leptotrombidium deliense (Acari: Trombiculidae).” Asian Pacific Journal of Tropical Biomedicine 2.1 (2012): S257-S259.
www.sciencedirect.com/science/article/abs/pii/S2221169112601701
- Sritabutra, Duangkamon, et al. “Evaluation of herbal essential oil as repellents against Aedes aegypti (L.) and Anopheles dirus Peyton & Harrion.” Asian Pacific Journal of Tropical Biomedicine 1.1 (2011): S124-S128.
www.sciencedirect.com/science/article/abs/pii/S222116911160138X
- Barbosa, Juliana DF, et al. “Structure–activity relationships of eugenol derivatives against Aedes aegypti (Diptera: Culicidae) larvae.” Pest management science 68.11 (2012): 1478-1483.
onlinelibrary.wiley.com/doi/abs/10.1002/ps.3331
- Kafle L, Shih CJ. Toxicity and repellency of compounds from clove (Syzygium aromaticum) to red imported fire ants Solenopsis invicta (Hymenoptera: Formicidae). J Econ Entomol . 2013;106(1):131‐135.
pubmed.ncbi.nlm.nih.gov/23448024/
- Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Eugenol (Clove Oil).
www.ncbi.nlm.nih.gov/books/NBK551727/
- Peixoto-Neves, Dieniffer et al. “Eugenol dilates rat cerebral arteries by inhibiting smooth muscle cell voltage-dependent calcium channels.” Journal of cardiovascular pharmacology vol. 64,5 (2014): 401-6.
www.ncbi.nlm.nih.gov/pmc/articles/PMC4224997/
- Lahlou, Saad, et al. “Cardiovascular effects of eugenol, a phenolic compound present in many plant essential oils, in normotensive rats.” Journal of cardiovascular pharmacology 43.2 (2004): 250-257.
www.researchgate.net/publication/8925226_Cardiovascular_Effects_of_Eugenol_A_Phenolic_Compound_Present_in_Many_Plant_Essential_Oils_in_Normotensive_Rats
- Al-Okbi, Sahar Y., et al. “Protective effect of clove oil and eugenol microemulsions on fatty liver and dyslipidemia as components of metabolic syndrome.” Journal of medicinal food 17.7 (2014): 764-771.
pubmed.ncbi.nlm.nih.gov/24611461/
- Shukri, Radhiah, Suhaila Mohamed, and Noordin Mohamed Mustapha. “Cloves protect the heart, liver and lens of diabetic rats.” Food chemistry 122.4 (2010): 1116-1121.
www.sciencedirect.com/science/article/abs/pii/S0308814610003870
- Peixoto‐Neves, Dieniffer, et al. “Eugenol dilates mesenteric arteries and reduces systemic BP by activating endothelial cell TRPV 4 channels.” British journal of pharmacology 172.14 (2015): 3484-3494.
pubmed.ncbi.nlm.nih.gov/25832173/
- Shahtalebi, Mohammad Ali, Atefeh Sadat-Hosseini, and Leila Safaeian. “Preparation and evaluation of clove oil in emu oil self-emulsion for hair conditioning and hair loss prevention.” Journal of HerbMed Pharmacology 5 (2016).
www.researchgate.net/publication/301204003_Preparation_and_evaluation_of_clove_oil_in_emu_oil_self-emulsion_for_hair_conditioning_and_hair_loss_prevention
- Aggarwal BB, Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol . 2006;71(10):1397‐1421.
pubmed.ncbi.nlm.nih.gov/16563357/
- Ghosh, Rita, et al. “Eugenol Causes Melanoma Growth Suppression through Inhibition of E2F1 Transcriptional Activity.” Journal of Biological Chemistry , 18 Feb. 2005, www.jbc.org/content/280/7/5812.short.
- National Toxicology Program. Carcinogenesis Studies of Eugenol (CAS No. 97-53-0) in F344/N Rats and B6C3F1 Mice (Feed Studies). Natl Toxicol Program Tech Rep Ser . 1983;223:1‐159.
pubmed.ncbi.nlm.nih.gov/12778213/
- Liu, Haizhou et al. “Clove extract inhibits tumor growth and promotes cell cycle arrest and apoptosis.” Oncology research vol. 21,5 (2014): 247-59.
www.ncbi.nlm.nih.gov/pmc/articles/PMC4132639/
- Atsumi, T., et al. “A Comparative Study of the Antioxidant/Prooxidant Activities of Eugenol and Isoeugenol with Various Concentrations and Oxidation Conditions.” Toxicology in Vitro , Pergamon, 17 June 2005, www.sciencedirect.com/science/article/abs/pii/S088723330500072X.
www.citationmachine.net/bibliographies/616422860?new=true
- Tajuddin et al. “Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative study.” BMC complementary and alternative medicine vol. 3 6. 20 Oct. 2003.
www.ncbi.nlm.nih.gov/pmc/articles/PMC270058/
- Tajuddin et al. “Effect of 50% ethanolic extract of Syzygium aromaticum (L.) Merr. & Perry. (clove) on sexual behaviour of normal male rats.” BMC complementary and alternative medicine vol. 4 17. 5 Nov. 2004.
www.ncbi.nlm.nih.gov/pmc/articles/PMC534794/
- Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Eugenol (Clove Oil).
www.ncbi.nlm.nih.gov/books/NBK551727/
- Gülçin, İlhami, et al. “Antioxidant Activity of Clove Oil – A Powerful Antioxidant Source.” Arabian Journal of Chemistry , Elsevier, 19 Sept. 2010, www.sciencedirect.com/science/article/pii/S1878535210001899.
- Thompson DC, Constantin-Teodosiu D, Moldéus P. Metabolism and cytotoxicity of eugenol in isolated rat hepatocytes. Chem Biol Interact . 1991;77(2):137‐147.
pubmed.ncbi.nlm.nih.gov/1991333/
- Mizutani T, Satoh K, Nomura H, Nakanishi K. Hepatotoxicity of eugenol in mice depleted of glutathione by treatment with DL-buthionine sulfoximine. Res Commun Chem Pathol Pharmacol . 1991;71(2):219‐230.
pubmed.ncbi.nlm.nih.gov/2047567/
- Barkin ME, Boyd JP, Cohen S. Acute allergic reaction to eugenol. Oral Surg Oral Med Oral Pathol . 1984;57(4):441‐442.
pubmed.ncbi.nlm.nih.gov/6584843/
- Tammannavar P, Pushpalatha C, Jain S, Sowmya SV. An unexpected positive hypersensitive reaction to eugenol. BMJ Case Rep . 2013;2013:bcr2013009464. Published 2013 Sep 18.
pubmed.ncbi.nlm.nih.gov/24049087/
- Klein AH, Carstens MI, Carstens E. Eugenol and carvacrol induce temporally desensitizing patterns of oral irritation and enhance innocuous warmth and noxious heat sensation on the tongue. Pain . 2013;154(10):2078‐2087.
pubmed.ncbi.nlm.nih.gov/23791894/
- Srivastava, K.C., and N. Malhotra. “Acetyl Eugenol, a Component of Oil of Cloves (Syzygium Aromaticum L.) Inhibits Aggregation and Alters Arachidonic Acid Metabolism in Human Blood Platelets.” Prostaglandins, Leukotrienes and Essential Fatty Acids , Churchill Livingstone, 3 Apr. 2004.
www.sciencedirect.com/science/article/abs/pii/095232789190070L
- Srivastava, K.C. “Antiplatelet Principles from a Food Spice Clove (Syzgium Aromaticum L).” Prostaglandins, Leukotrienes and Essential Fatty Acids , Churchill Livingstone, 3 Apr. 2004.
www.sciencedirect.com/science/article/abs/pii/095232789390116E
- Hartnoll G, Moore D, Douek D. Near fatal ingestion of oil of cloves. Arch Dis Child . 1993;69(3):392‐393.
pubmed.ncbi.nlm.nih.gov/8215554/